Abstract
Primary or focal hyperhidrosis is a dermatologic condition characterized by excessive sweat production surpassing the thermoregulation needs, affecting focal zones like palms, soles, axillae, or craneofacial region. Its etiology remains uncertain, although evidence suggests there is an important genetic component. The diagnosis requires an exhaustive clinical history that allows the clinician to rule out secondary and pharmacological causes. Some qualitative and quantitative testes may be useful in the diagnosis. Given the important impact on patient's life quality, there are different therapeutical options available, from topical agents and medical devices, to systemic therapies and surgical procedures. These vary a lot in terms of effectiveness, safety, tolerability, and cost, and thus therapy choice must be individualized, taking into account the quality of life affected, the location of the disease, contraindications, and possible complications.
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