Abstract
Retinoblastoma is a type of cancer that arises from the loss of both copies of the RB1 gene that normally suppress the development of this neoplasm in retinal cells. Retinoblastoma can affect one or both eyes and 5% of children with inherited retinoblastoma have been documented to associate a midline brain tumor. Without prompt and effective treatment, this disease can spread through the optic nerve or the hematogenous pathway and cause death. It remains unknown what causes the genomic damage to the RB1 gene, but retinoblastoma develops as a pathology in all ethnic groups, regardless of geographic environment and social stratum, therefore its early diagnosis and management implies a general responsibility among physicians.
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Copyright (c) 2021 Juan Diego Vargas Cedeño, Catalina Castrillo Hine, Leslie Argüello Cruz