Abstract
Lithium is a psychiatric pharmacological agent used as a mood stabilizer in bipolar disorder and has been shown to be effective in preventing manic and depressive symptoms and suicidal behavior. However, its neuroprotective properties and its intervention neuronal inflammatory pathways, postulate it as a drug that could be used in pathologies with cognitive impairment. It produces neuroprotective effects in a large number of neuronal populations involved in both behavioral and motor circuits. It has anti-inflammatory and antioxidant benefits at the neuronal level, which makes it extremely useful as a treatment for neurodegenerative diseases. A great ability for neurogenesis and neuroprotection is demonstrated, mainly at the level of the hippocampus. Their limitations and contraindications should be taken into account when evaluating their efficacy. The review was carried out with the aim of analyzing the use, efficacy and benefits of lithium as a neuroprotective and regenerative agent in degenerative neurological pathologies.
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Copyright (c) 2022 Julissa Barrios, Maria Del Sol Gomez, Maria Alejandra Godoy, Alberto Cervantes