A Antidepressants and pharmacological interactions with risks of serotonergic toxicity.
Revista Ciencia y Salud / eISSN: 2215-4949 / https://revistacienciaysalud.ac.cr/ojs

Vol. 7 No. 3 (2023)Artículos

Vol. 7 No. 3 (2023)

A Antidepressants and pharmacological interactions with risks of serotonergic toxicity.

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Keywords

serotonin syndrome
serotonin toxicity
antidepressants
selective serotonin reuptake inhibitors
monoamine oxidase inhibitors

How to Cite

Sequeira Quesada, C. M. ., Lin Wu, E. L. W., & Lin Wu, A. (2024). A Antidepressants and pharmacological interactions with risks of serotonergic toxicity. Revista Ciencia Y Salud, 7(3), 55–69. https://doi.org/10.34192/cienciaysalud.v7i3.630 (Original work published September 13, 2023)

Abstract

Serotonin syndrome is a potentially lethal disease caused by excessive serotonin activity at the synapses in the central and peripheral nervous system. Currently, there is an increase in the use of antidepressants in the United States, which has contributed to being one of the most frequent causes of toxicity and overdose, thus increasing the risk of serotonin syndrome. Also, there are several drugs and mechanisms involved, the most common interactions are between monoamine oxidase inhibitor antidepressants, selective serotonin receptor inhibitors, and serotonin and norepinephrine reuptake inhibitors. In general, the mechanisms in place alter the metabolism, release, and activation of serotonin receptors. The clinical manifestations are usually autonomic hyperactivity, mental alterations, and muscular hyperactivity, the degree of symptoms varies from mild, moderate, and severe; most are mild and resolve after withdrawing the medication or serotonergic drug. Meanwhile, severe cases are rare and can be complicated by hemodynamic instability, hyperthermia, rhabdomyolysis, and arrhythmias; Therefore, it requires specific treatment. Compared to other criteria, the most specific and sensitive are the Hunter criteria for serotonergic toxicity, however, this remains in dispute and subject to change in the future. Even so, there are few cases reported or recognized by health personnel. In any case, the objective of this article is to summarize the most recent information about serotonin syndrome, and provide the clinician with the skills to diagnose, treat, and know how to prevent more cases.

https://doi.org/10.34192/cienciaysalud.v7i3.630
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright (c) 2023 Carlos Mario Sequeira Quesada, Edwin Lin Wu Lin Wu, Allan Lin Wu

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