Biología del desarrollo de los ovocitos y enfoques para superar su disminución con el aumento de la edad en las mujeres

Abstract

The number of oocytes and follicles that a woman will carry in her ovaries during her life is established from fetal development and decreases with age, especially after 32 years of age. In addition to a decrease in quantity, there is can also be a decrease in quality. The growing tendency of women over 35 years of age to delay pregnancy increases procedures with assisted reproductive technologies (ART) due to infertility. For aged women (AW), in vitro fertilization (IVF) is the most effective treatment compared to in vitro maturation (IVM) and ovarian stimulation/intrauterine insemination. The cumulative live birth rate (CLBR) and the pregnancy rate are used to measure the quality and success of these procedures. Approaches that can be used in AW to increase their chance of pregnancy are oocyte cryopreservation, controlled ovarian stimulation, preimplantation genetic testing, and oocyte donation.