Abstract
Infliximab is the first human chimeric monoclonal antibody composed of human constant regions and murine variable regions that aims to produce an anti-inflammatory action that specifically decreases tumor necrosis factor alpha. This medicine is indicated in the treatment of various diseases such as: rheumatoid arthritis, psoriasis, Crohn's disease, and ulcerative colitis. In this review, different aspects related to the production of the drug, its pharmacological and pharmacokinetic properties, as well as its role in the diseases, are briefly addressed to provide an updated approach to the development and clinical use of this chimeric monoclonal antibody.

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Copyright (c) 2025 Mildred Angelica Sauce Guevara, Erika Palacios Rosas , Alvaro Asaf Guerra Martinez